The Oscar-winning actress was working on new movie The Hive when the incident occurred at around 10pm.
An ambulance was immediately called and took the beauty to the nearby Cedars Sinai medical centre in Los Angeles.
On set sources say she either fell or was hit by a falling object.
An ambulance took Halle,45, to the hospital and the set was swiftly shut down.
Halle’s representative has yet to comment.
It is the second time this month an actress has been injured on a set.
Kristin Chenoweth was recently rushed to hospital after being hit by a piece of lighting equipment on The Good Wife.
Her injuries were believed to be minor and she was soon released from the Bellevue Hospital in the Williamsburg area of Brooklyn, New York.
Kristin – who has also appeared in Glee – later thanked fans for wishing her well.
Her representative said: “Kristin has been released from the hospital and is home recovering. She thanks everyone for their prayers and well wishes.”
